Coronavirus

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chaos
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Re: Coronavirus

#741 Post by chaos » Fri Jun 26, 2020 10:37 am

https://www.nbcmiami.com/news/local/flo ... 0/2254382/

Florida Again Sets Daily Record for New Coronavirus Cases With Nearly 9,000
More than 33,200 new COVID cases have been confirmed in Florida in just the past seven days
Published 2 hours ago • Updated 14 mins ago


Florida reported more than 8,900 new COVID-19 cases Friday, a new daily record
The previous daily record, set Wednesday, saw 5,506 new cases


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chaos
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Re: Coronavirus

#742 Post by chaos » Fri Jun 26, 2020 10:44 am


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Re: Coronavirus

#743 Post by chaos » Fri Jun 26, 2020 12:16 pm

https://www.latimes.com/science/story/2 ... d-realized

Inside the body, the coronavirus is even more sinister than scientists had realized

By MELISSA HEALYSTAFF WRITER
JUNE 26, 20208 AM

The new coronavirus’ reputation for messing with scientists’ assumptions has taken a truly creepy turn.

Researchers exploring the interaction between the coronavirus and its hosts have discovered that when the SARS-CoV-2 virus infects a human cell, it sets off a ghoulish transformation. Obeying instructions from the virus, the newly infected cell sprouts multi-pronged tentacles studded with viral particles.

These disfigured zombie cells appear to be using those streaming filaments, or filopodia, to reach still-healthy neighboring cells. The protuberances appear to bore into the cells’ bodies and inject their viral venom directly into those cells’ genetic command centers — thus creating another zombie.

The authors of the new study, an international team led by researchers at UC San Francisco, say the coronavirus appears to be using these newly sprouted dendrites to boost its efficiency in capturing new cells and establishing infection in its human victims.

Their research was published Friday in the journal Cell.

The scientists also believe they have identified several drugs that could disrupt the viral takeover of cells and slow the process by which COVID-19 takes hold. These compounds, many of which were designed as cancer treatments, seem likely to work because they block the chemical signals that activate filopodia production in the first place.

Among the seven drugs they identified as potentially useful against COVID-19 are Silmitasertib, a still-experimental drug in early clinical trials as a treatment for bile duct cancer and a form of childhood brain cancer; ralimetinib, a cancer drug developed by Eli Lilly; and gilteritinib (marketed as Xospata), a drug in use already to treat acute myeloid leukemia.

The new research emerges from an ambitious effort to identify promising COVID-19 treatments using the science of “proteomics,” the interactions among proteins. Scientists set out to identify the chemical signals and cascading chain of events that take place when a virus meets and overtakes a host cell. Then, they look for drug compounds that could scramble those chemical signals and disrupt the process of infection.

Until now, the process by which the coronavirus was thought to infect cells was pretty run-of-the-mill for a virus: It found receptors on the surface of the cells that line humans’ mouth, nose, respiratory tract, lungs and blood vessels.

Like space invaders in a science fiction tale, the tiny virus was known to dock on the surface of the much larger cell. A viral landing party came aboard and hijacked the cell’s usual function, making it a factory for its replication.

Image
Tendrils reach out from a coronavirus-infected cell.(UCSF)

The discovery that the coronavirus initiates the sprouting of filopodia in infected cells suggests that it has, at some point in its evolution, developed more than one way to ensure it gets passed quickly from cell to cell.

Typically, a rapid rise in infected cells will raise a victim’s viral load, make her feel sick and promote the transmission of the virus to other people. UC San Francisco’s Nevan Krogan, one of the paper’s senior authors, said there is much about the coronavirus that doesn’t match scientists’ expectations.

But the discovery of filopodia in coronavirus-infected cells suggests that this virus has developed more than one way to wheedle its way into cells and establish itself as a force to be reckoned with.


“It’s just so sinister that the virus uses other mechanisms to infect other cells before it kills the cell,” Krogan said. Other researchers include scientists from Mt. Sinai in New York, Rocky Mountain Labs in Montana (where these electron microscopy images were made), the Pasteur Institute in Paris and the University of Freiburg in Germany.

Image
Another cell infected by the coronavirus.(UC San Francisco )

Cells sprouting filopodia not only look creepy. They keep some pretty nasty company as well.

Vaccinia, a member of the poxvirus family that causes smallpox, uses filopodia that sprout from infected cells to “surf” toward those cells and inject them with more viral particles, a 2008 study found. HIV and some influenza viruses have been known to use filopodia to enhance their ability to break and enter into cells. Many viruses alter the exoskeleton of the cells they infect, and inducing filopodia is one way they do it, said Columbia University virologist Angela L. Rasmussen. And while enhancing infection is one role they often play, there are many others.

But Krogan said even those viruses do not seem to set off the prolific growth of filaments that was seen by his colleagues on coronavirus-infected cells. The branching tentacles protruding from those cells were highly unusual, he said.

Image
A coronavirus-infected cell reaches out to new hosts.(UC San Francisco)

Columbia University microbiologist Stephen P. Goff urged caution in assuming that filopodia are necessarily behaving as a second mode of infecting cells with virus.

“It’s intriguing and a really cool observation,” Goff said. The study’s striking images show that the filopodia contain a lot of virus and that in the lab, inhibiting their growth seemed to reduce viral replication. This strongly suggests that filopodia are somehow amping up the virus’ ability to infect cells, he acknowledged.

“But we don’t yet know what stage [of infection] is affected” by the strange protrusions, he said. “It will be great fun to find out.”


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Re: Coronavirus

#744 Post by Juana » Fri Jun 26, 2020 9:36 pm

That is very interesting and utterly terrifying.

In other news now the rivers, lakes, and bars are shut down here. Glad the one I still have some stake in has stayed "closed" since its been skeleton crew since March.

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Re: Coronavirus

#745 Post by chaos » Sat Jun 27, 2020 11:32 am

Opening day at Trader Joe's in North Hollywood

Part I
Part II

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Larry B.
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Re: Coronavirus

#746 Post by Larry B. » Sat Jun 27, 2020 2:40 pm

Do strangers in the US ever interact without one accusing the other of harassment, racism, sexism, violation of freedoms, sexual abuse, etc?

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Pandemonium
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Re: Coronavirus

#747 Post by Pandemonium » Sat Jun 27, 2020 5:55 pm

Larry B. wrote:
Sat Jun 27, 2020 2:40 pm
Do strangers in the US ever interact without one accusing the other of harassment, racism, sexism, violation of freedoms, sexual abuse, etc?
This shit happens more and more all the time. Most of the time it's nonsense like the above clips from the Trader Joes store where you have people looking to be outraged (the several women) and have confrontations and people who are all too willing to create situations to bait those kind of people (the "bebe" woman). Social media narcissism and the proliferation of cell phone video culture all plays into it.

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Re: Coronavirus

#748 Post by Larry B. » Sat Jun 27, 2020 7:23 pm

Pandemonium wrote:
Sat Jun 27, 2020 5:55 pm
Larry B. wrote:
Sat Jun 27, 2020 2:40 pm
Do strangers in the US ever interact without one accusing the other of harassment, racism, sexism, violation of freedoms, sexual abuse, etc?
This shit happens more and more all the time. Most of the time it's nonsense like the above clips from the Trader Joes store where you have people looking to be outraged (the several women) and have confrontations and people who are all too willing to create situations to bait those kind of people (the "bebe" woman). Social media narcissism and the proliferation of cell phone video culture all plays into it.
That reminded me of something that happened last week. I was talking to a friend and she said she felt sad and very confused. She remembered that when she was 14-15, she used to talk via MSN Messenger with a friend’s older brother, who was 28 at the time. I asked if anything sexual happened, she said no. “Did he ever said anything inappropriate to you?” No.

So, I didn’t want to be mean, but I couldn’t wrap my head around why she was crying. Is it odd that a 28 year old is messaging with a 14 year old? Sure, but that just removes all context from it. My friend used to visit them often, this guy would drive them to concerts and look after them, etc. But she was sad and crying because ‘she felt she had been too naive and helpless.’ NOTHING HAPPENED to her. She was feeling victim of something that could have happened.

:conf:

Nothing happened to you. The fuck are you crying about. It’s like there’s this profound need to be part of a victimised group... when we are all already part of it. You don’t need to have been groped to be a part of it. And if you weren’t groped but someone somewhere might’ve thought about groping you, that’s not something you should be feeling victimised for, for fucks sake.

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Re: Coronavirus

#749 Post by chaos » Sat Jun 27, 2020 8:36 pm

Pandemonium wrote:
Sat Jun 27, 2020 5:55 pm
people looking to be outraged (the several women) and have confrontations and people who are all too willing to create situations to bait those kind of people (the "bebe" woman).
?

The women speaking to the bebe woman are Trader Joe employees. The bebe woman says (in 2nd clip) "that man" harassed her for not wearing a mask.
I assume the employees asked the bebe woman to either put on a mask or leave after her encounter with the man/customer.

I guess I have taken for granted the normative obeyance of the no mask-no service stance in my area.

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Re: Coronavirus

#750 Post by kv » Sat Jun 27, 2020 8:43 pm

It's moronic...you have to wear shoes, shirts, shorts or pants...why aren't they screaming about that?
:banghead:
It's not like if you can't wear a mask they won't shop for you...just ask for a fucking manager and be an adult

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Pandemonium
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Re: Coronavirus

#751 Post by Pandemonium » Mon Jun 29, 2020 9:25 am

What is it with MILFs and temper tantrums in stores over having to wear a mask?


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mockbee
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Re: Coronavirus

#752 Post by mockbee » Mon Jun 29, 2020 9:51 am

Misogyny.

In our society women's only real value is their looks.

We're trying to do better, but....unfortunately for the most part that is still pervasive and the truth in our media saturated/appearance obsessed culture.

Put a mask on. What do you have left. Little to no value, in our society. Yeah, sure, raise the kids, but we put little to no value on that either. Get the nannys from central america or pay daycare minimum wage to do that job....

:noclue:

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chaos
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Re: Coronavirus

#753 Post by chaos » Mon Jun 29, 2020 11:06 am

(There is a 30 second commercial in the beginning of clip; the QAnon guy at .30 and 1:30 is :crazy: )

Why is a state mandate unenforceable in California?

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Re: Coronavirus

#754 Post by chaos » Mon Jun 29, 2020 11:08 am

Bebe woman update:

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mockbee
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Re: Coronavirus

#755 Post by mockbee » Mon Jun 29, 2020 11:41 am

chaos wrote:
Mon Jun 29, 2020 11:06 am


Why is a state mandate unenforceable in California?
Oh, it's enforceable. https://www.capradio.org/articles/2020/ ... perts-say/
But the police know it's not in their best interest to enforce it.

Liberals love enacting laws, but hate enforcing them. Laws are for all the other people, not me.
Just like increased taxes are for all the OTHER people, the RICH people! (not me....)

And even if it is Cali, it is still first and foremost the West.
Don't tell me what to do.... law number one.

:noclue:

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Re: Coronavirus

#756 Post by chaos » Mon Jun 29, 2020 12:01 pm

The park employees outside Runyon Canyon simply "remind" people of the mandate. They seem to have no authority to deny entry.

In Massachusetts, you can be denied entry and issued a fine. People will get arrested if they become belligerent. When I see the stuff going on in other states, it's as though I am watching something from the Twilight Zone.

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Re: Coronavirus

#757 Post by chaos » Mon Jun 29, 2020 1:07 pm

https://www.washingtonpost.com/nation/2 ... pdates-us/

June 29, 2020
3:41 p.m. EDT

Florida reports high in rolling seven-day average of new cases for 22nd day in a row

Florida reported 5,266 new cases of the coronavirus Monday, as well as 28 deaths, bringing the total number of cases and deaths in the state during the coronavirus pandemic to 146,341 and 3,447, respectively.

Although the new daily case number was lower than the day before, as a rolling seven-day average it was a record high at 6,589, according to data compiled by The Washington Post.

For the past 22 days, the rolling average has continually set a record each day. A number of other states are on similar streaks — South Carolina has set a record on its rolling seven-day average for 21 days, while Texas has for 19 days.

Florida’s rolling seven-day average has risen by 102 percent since a week ago, an increase second only to Louisiana, where the seven-day average is 123 percent higher than a week ago. The state’s seven-day average of new deaths has also increased: It is now 15 percent higher than last week.
By Adam Taylor
https://www.washingtonpost.com/nation/2 ... pdates-us/

June 29, 2020
3:25 p.m. EDT

Jacksonville, Fla., host of Republican National Convention, orders mask-wearing

Jacksonville, the largest city in Florida and host of the Republican National Convention planned for late August, announced Monday that masks will be mandatory in public and indoor locations, as well as in “other situations where individuals cannot socially distance.”

City spokeswoman Nikki Kimbleton told The Washington Post that whether the mandate applies to the convention will be addressed “as we get closer to the event,” noting that it “is still two months away.”

The mask order, which goes into effect Monday evening, is a turn for Mayor Lenny Curry. The former Republican Party of Florida chairman has been “ideologically resistant to passing government mandates,” Politico reported. He said a week ago that he did not plan to issue an order on masks, according to News4Jax, although he encouraged mask-wearing as “the responsible thing.”

“Wearing a mask is not a political statement,” the news station quoted Curry as saying at the time. “It’s about protecting yourself and your loved ones and your neighbors.”

Republicans announced earlier this month that the premier festivities of their convention would be held in Jacksonville instead of Charlotte, after North Carolina officials balked at Trump’s demand to host a mass gathering amid the coronavirus pandemic.

The GOP began its last-minute search for a new site after the president tweeted that he would move the event if he couldn’t get a commitment for large-scale crowds to be permitted. RNC officials had called for a convention with tens of thousands of attendees. They pledged to conduct temperature checks and make masks available.

Trump at one point phoned North Carolina Gov. Roy Cooper (D) to lay out his demands for the convention, telling him “we can’t do social distancing.” State officials pressed for a detailed plan on how the convention would be safely hosted.

By June 11, the RNC had announced that Trump’s renomination speech and other major convention features would move to Jacksonville.



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Re: Coronavirus

#758 Post by Hokahey » Mon Jun 29, 2020 7:37 pm

The 7 day rolling average for deaths appears to be the lowest its been since this started. I'm very curious if that will tick up. One would certainly think, but if it is indeed mostly younger people driving the new/rebound wave and they're not going on to infect more vulnerable people, then that's one positive i suppose.

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Re: Coronavirus

#759 Post by Charles » Tue Jun 30, 2020 1:56 am

Larry B. wrote:
Sat Jun 27, 2020 2:40 pm
Do strangers in the US ever interact without one accusing the other of harassment, racism, sexism, violation of freedoms, sexual abuse, etc?
Very rare...

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Re: Coronavirus

#760 Post by mockbee » Thu Jul 02, 2020 1:49 pm

Today in Oregon.

Would it be weird if I said this doesn't surprise me in the least?
Even the "F*** the governor" response by a State Trooper in a liberal town...

:noclue:
Oregon State Police don’t wear coronavirus masks while patronizing coffee shop, despite governor’s order
By Brad Schmidt | The Oregonian/OregonLive

https://www.oregonlive.com/coronavirus/ ... order.html

Image


A group of Oregon State Police troopers appeared to defy Gov. Kate Brown’s statewide mask order while in uniform Wednesday, entering a Corvallis coffee shop without wearing required face coverings, video obtained by The Oregonian/OregonLive shows.

The store’s assistant manager, Travis Boss, said he told the first trooper who arrived that the trooper needed to wear a mask.

“Governor Brown has no authority to take our civil liberties. We aren’t going to wear masks,” the trooper allegedly said, according to a written statement from Boss provided to the newsroom.

The trooper proceeded to place his order, Boss said in an interview, offering a foul-mouthed retort to the governor’s mandate that masks be worn within indoor public spaces.

“He said, ‘F---, Kate Brown,’” Boss recalled.

The trooper’s alleged comments came on the same day that Brown’s statewide mask order went into effect, and just hours before Brown implored Oregonians to wear facial coverings as a “simple, common sense way to protect yourself and others” during the coronavirus pandemic.

Three other law enforcement officers entered the business moments later and also refused a request to wear masks, Boss said. Boss said he felt compelled to fulfill their drink orders because they were in uniform, even though he said he had sent other patrons away earlier for not wearing masks.

The incident represents an extraordinary example of the difficult position that Brown has put some businesses in as they work to enforce the potentially divisive rule. Workers in shops across Oregon have been left to impose the mask mandate with the knowledge that some customers may disobey or, as videos across the country have shown, create made-for-internet spectacles.


Allan’s Coffee & Tea reported Wednesday’s incident to local police. Oregon State Police responded by launching an internal investigation, said Capt. Timothy Fox, an agency spokesman.


“The involved trooper has been placed on administrative leave,” Fox said in a statement. “OSP is early in the investigation, but if found to be true, we are thoroughly disappointed and expect our troopers to follow the governor’s executive orders and be examples in the community.”

Fox confirmed Thursday that all four were state troopers but he would not name the trooper on leave.

Oregon State Police Superintendent Travis Hampton addressed the issue Thursday morning, less than three hours after The Oregonian/OregonLive published this story online. Hampton wrote on Twitter that the conduct described in the article was “embarrassing and indefensible,” especially as thousands protest each night in Oregon for police accountability in the wake of George Floyd’s death.

“Let me be clear, Oregon State Police Troopers are not above the law and this conduct is being immediately addressed,” Hampton wrote. “As the leader of the Oregon State Police, I would like to offer my apology to the coffee shop employees and the community.”




Brown also issued a statement Thursday afternoon, echoing Hampton’s response.

“It is inexcusable that a few Oregon State Troopers disregarded my face covering requirement yesterday, and ignored a request from a fellow Oregonian to follow the rule,” she said. “Oregon State Police Superintendent Hampton and I agree that their actions and behaviors were absolutely unacceptable.”

The incident in Corvallis underscores the tension nationwide among some people over whether masks should be worn to prevent the spread of coronavirus, which has killed more than 128,000 Americans, including 208 in Oregon.

Although the Centers for Disease Control and Prevention recommends wearing masks in public, President Donald Trump and Vice President Mike Pence have repeatedly refused to don facial coverings. Masks have become a flashpoint that often fall along political lines.

The co-owners of Allan’s Coffee & Tea, Robert and Kathryn Morgan, said Wednesday they respect the work of troopers and did not want the incident to turn political. In fact, the business brews a special “Oregon State Police blend” at their shop in Albany, near the troopers’ offices.

The co-owners said they simply want to comply with Brown’s mask mandate and keep their business open for patrons.

Brown’s mask order does not explicitly name coffee shops but applies to restaurants, bars, breweries, brewpubs, wineries, tasting rooms and distilleries. Masks “are not required while eating or drinking,” according to state guidance.

“We’re in this to follow the mandate,” Robert Morgan said, “to try to get back to some form of normalcy somewhere down the road.”

Wednesday’s incident began at about 8:30 a.m. when a trooper wearing shorts and a bullet-proof vest entered the Allan’s location on Northwest Monroe Avenue, next to Oregon State University.

Video shows the unmasked trooper walking to the counter, where Boss greets him. The video, provided to the newsroom by the business, does not have audio.

Boss said the trooper is a regular, and they have a friendly rapport.

“Hey, you gotta have your mask on,” Boss recalled saying. Boss said the trooper declined.

The video shows Boss and the trooper talking for more than 30 seconds before Boss grabs a cup, giving it to the nearby barista to use to fill the order.

Boss said he initially tried to diffuse the situation by asking the trooper what he thought about Brown’s order requiring masks. That prompted the alleged response that it would be a violation of civil liberties, Boss said.

Boss said the trooper also noted that police would not be enforcing violations and said something like: “I’m not going to wear a mask and none of us are,” in anticipation of more troopers arriving.

That left Boss in a weird situation.

“He’s a state trooper, he’s in uniform,” Boss said. “He’s more or less saying, ‘This is how it’s going to be, and this is what I want.’”

The video shows three more people in uniform arrive, none wearing masks. One wears a vest that appears to say “State Trooper,” video footage shows. The second wears a vest that appears to say “State Police.” The third does not have a vest over his uniform but has a star-shaped badge pinned to his chest.

After they placed their orders, the group sits at a table near the door. The video footage shows several other customers enter the business later, one of whom does not wear a mask when he places an order with the barista.

The troopers remain for about 10 minutes, according to the video footage.

Boss said two of the troopers are regulars and he expected them to leave after getting their drinks, which they usually do. Boss said he contacted the owners to determine what he should do next.

Boss said he was instructed to tell them that Corvallis police had been contacted and they should leave. The video shows Boss approaching them at their table, and the troopers stand up to go.

One of the troopers allegedly said, “That’s Corvallis for you,” as they walked out, Boss recalled.

Having law enforcement officers in the shop without wearing masks created a “horrible situation,” Boss said, upsetting some customers who questioned why they had to wear masks when the police did not.

Kathryn Morgan said they expected some customers would not want to comply with Brown’s mask order. But she found it “pretty upsetting” that the troopers would not wear masks, putting their business in an awkward position of being at risk for not following the rules.

“It’s sad,” she said. “These are people in a position of power and leaders in the community. I think we look to them as examples. For them not to be following the orders, whether or not they agree with it, is telling.”

A lieutenant from the Oregon State Police arrived at the coffee shop later in the morning to talk with Boss, and Robert Morgan participated via speaker phone. Boss said he explained what happened and what the trooper said, including the alleged use of profanity.

“I don’t hold any grudges against him,” Boss said. “I feel bad about the possible backlash that might come from this, on them, and at the same time I know that’s not my doing.”

Robert Morgan said the lieutenant didn’t apologize for the incident but assured them it would not be swept under the rug.

All the same, Robert Morgan said the lieutenant told them they could share the information with whomever they wanted but “but they would prefer to keep it as an internal matter.”

Robert and Kathryn Morgan said they wrestled with whether to go public but decided to do so, hoping it would ensure everyone follows the mask order with the goal of reducing coronavirus spread and helping businesses stay open.

Brown’s office didn’t respond to a request for comment Wednesday evening.

But earlier in the day – just hours after the incident – Brown had told reporters during a morning news conference that she expected businesses to comply with the mask order to protect patrons and employees.

“I know that Oregonians will literally vote with their feet,” she said. “They will go to businesses that are taking extra efforts to ensure that their customers and their clients are safe and protected from COVID-19.”

Brown made clear that violation of the order could be a misdemeanor, although she did not expect police to write tickets nor did she want businesses to contact officers for help with disobedient customers.

“We shouldn’t have to be in the position of calling the police to enforce face coverings,” Brown said. “It’s just common sense, folks.”

-- Brad Schmidt; bschmidt@oregonian.com; 503-294-7628; @_brad_schmidt


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